VHH or Nanobody is the next generation monoclonal antibody, whichn is a Single domain antibody (sdAb) reserving only one single antigen recognizing domain from camelid heavy chain antibody. With size of only ~ 15 kDa, Nanobody dispay numerous advantages over conventional antibody and it's derivatives, such as higher tissue penetration capability, more accessible to hidden epitopes, higher stability(thermal and pH resistant), solubility (aggregation avoidance) and binding affinity.
Anti-Escherichia coli trxA/Thioredoxin Nanbody/VHH is specifically designed to target specifically Escherichia coli trxA/Thioredoxin. This monovalent, recombinant single-domain antibody is derived from the variable region of the heavy chain of Alpaca pacos. Based on immunoelectrophoresis and ELISA assays, this Nanobody/VHH demonstrates selective reactivity with the target specifically, with no detectable cross-reactivity to other antigens.
